Good business performance gives Boehringer Ingelheim tailwind for investment in R&D

1. R&D investment up 11.7% to 4.1 billion EUR in 2021 (20.0% of net sales)
2. More than 25 billion EUR investment in R&D and 7 billion EUR in capital expenditure over the next five years
3. Human Pharma pipeline acceleration: up to 15 new product launches expected until 2025

INGELHEIM, GERMANY - Media OutReach - 6 April 2022 - In 2021, Boehringer Ingelheim again stepped up its annual investments in R&D to a new high in its 137-year history. The company spent 4.1 billion EUR on R&D (2020: 3.7 billion EUR), up 11.7%. R&D investments in Human Pharma rose to 3.7 billion EUR (2020: 3.3 billion EUR), while investments in Animal Health were up 1% to 416 million EUR (2020: 412 million EUR).

"2021 was a good year for patients, for animal owners and for our company. We expanded our contribution to transforming human and animal lives and further strengthened our combined pipeline," explained Hubertus von Baumbach, Chairman of the Board of Managing Directors. "Accordingly, we also intensified our efforts in Research and Development and achieved significant medical progress, including three breakthrough therapy designations granted by the US FDA for innovative medicines in Human Pharma. In Animal Health, we laid the foundation for the launch of innovative new solutions for companion animals and livestock in 2022 and 2023.

"We present these results at a time when war has been brought back to Europe," continued von Baumbach. "Our thoughts are with all Ukrainians. The aggression against the country is heartbreaking. We are supporting those seeking refuge and those in need in Ukraine, through short-term and long-term financial support, through product donations and supply of medicines, and many of our employees engage in support initiatives using our volunteering days program. We all hope that this horrific situation will end soon."

Growth across all businesses

Despite the ongoing COVID-19 challenges, 2021 was a successful year. Boehringer Ingelheim recorded net sales of 20.6 billion EUR (2020: 19.6 billion EUR), a 5.4% increase compared to the previous year. Adjusted for currency effects, net sales rose by 7.5%.

Operating income at Group level rose to 4.7 billion EUR (2020: 4.6 billion EUR). Income after taxes saw an 11.2% year-on-year increase to 3.4 billion EUR (2020: 3.1 billion EUR). Cash flow from operating activities decreased slightly by 117 million EUR to 3.9 billion EUR (2020: 4.0 billion EUR). At the end of 2021, the equity ratio stood at 48% (2020: 47%).

"All our businesses contributed to the solid financial results in 2021, a strong achievement, especially when considering the overall pandemic and economic situation. As a result, we can continue making significant investments and have strengthened our overall financial basis – and thus our independence," said Michael Schmelmer, Member of the Board of Managing Directors responsible for Finance and Group Functions. "The extraordinary commitment of all our employees in a second pandemic year drove our achievements. Working conditions were often challenging, both for those of us who worked from home on an almost permanent basis and for those who worked under restricted conditions on our sites. In times of need, we all stand up for each other. This makes me feel positive and optimistic and is particularly important for the long-term success of our company."

Human Pharma - Significant progress in late-stage R&D pipeline

The R&D pipeline in Human Pharma comprises more than 100 clinical and preclinical projects. Based on the progress of the later stage projects, the pipeline has the potential to deliver up to 15 new product launches until 2025. A key focus in research is to gain a deeper understanding of the connections between different diseases.

Animal Health – Higher net sales in a very competitive market

The Animal Health business of Boehringer Ingelheim is a globally leading provider of vaccines, therapeutics and preventative care offerings that protect animals from disease and pain. In 2021, the Animal Health business significantly increased its net sales in a highly competitive market and grew by 6.2%*, with net sales of 4.3 billion EUR (2020: 4.1 billion EUR).

Biopharmaceutical production – One of the leading providers in the industry

Boehringer Ingelheim is one of the leading manufacturers of biopharmaceuticals, both for its own portfolio and for partners in the industry. 60% of the top 20 pharmaceutical companies and innovative biotech firms are clients of Boehringer Ingelheim's Biopharmaceutical Contract Manufacturing business, known under the brand name Boehringer Ingelheim BioXcellence^TM. The biopharmaceuticals business achieved net sales of 917 million EUR in 2021 (2020: 837 million EUR), up 9.5%* due to strong demand for our customers' products.

Investments in tangible fixed assets remain at a high level

In 2021, the company invested 968 million EUR (2020: 1.05 billion EUR) in tangible fixed assets, including the large-scale production facility for biopharmaceutical products (LSCC) in Vienna, Austria, which was inaugurated in October 2021, and the new development center for biopharmaceutical medicines (BDC) in Biberach, Germany. Restricted construction activities due to the COVID-19 pandemic had an impact on the investment sum.

Outlook for 2022: Boehringer Ingelheim expects a slight year-on-year increase in net sales on a comparable basis

The ongoing COVID-19 pandemic, the geopolitical tensions in Europe and a challenging industry environment are expected to have an impact on the results of Boehringer Ingelheim. For 2022, the company expects to achieve a slight year-on-year increase in net sales on a comparable basis. For the next five years, plans are to invest over 25 billion EUR in its research pipeline. In addition, capital expenditures for novel production technologies and a cutting-edge supply network are planned, with well over 7 billion EUR of investments targeted for the next five years. This includes further expansion of our biopharmaceutical production capacities.

*year on year and adjusted for currency effects

2021 Annual Report at https://annualreport.boehringer-ingelheim.com/

Boehringer Ingelheim

Boehringer Ingelheim is working on breakthrough therapies that transform lives, today and for generations to come. As a leading research-driven biopharmaceutical company, the company creates value through innovation in areas of high unmet medical need. Founded in 1885 and family-owned ever since, Boehringer Ingelheim takes a long-term perspective. More than 52,000 employees serve over 130 markets in the three business areas, Human Pharma, Animal Health, and Biopharmaceutical Contract Manufacturing. Learn more at www.boehringer-ingelheim.com.


Addendum:

Statement from Dr. Armin Wiesler, Regional Country Managing Director & Head of Animal Health, Boehringer Ingelheim Regional Operating Unit, ASEAN, Korea, Australia & New Zealand (ROPU ASKAN)

Introducing ROPU ASKAN

"Starting January 1, 2022, we are pleased to welcome Australia and New Zealand, into our overall regional scope of business operations. Our region name is now called ASKAN – ASEAN, Korea, Australia & New Zealand. Together, we form a strong regional team that is committed to providing crucial medicines to patients and animals. We also recognize the opportunity for talent development for our people within this new region. Our recent recognition as a Global Top Employer is testament to our commitment for employee engagement and growth."

Our Performance & Growth in ASKAN

"The year 2021 was a successful year for us, despite the current COVID-19 pandemic and the challenges it has posed to our patients, partners, customers and our people. Our teams across the region came together as one team to really focus on delivering medicines to the people and animals that need it the most."

"In 2021, we continue to retain our leading position as an Animal Health business across ASKAN. This is led by our Pets Business and our parasiticides products, with strong performances in also our swine, poultry and ruminant businesses."

"In our Human Pharma business, we are leading in the SGLT2 category in the diabetes business, and we are the No.1 company in the non-insulin market overall."

"Globally we also launched Sustainable Development for Generations – a global commitment to sustainability goals that are focused on meeting areas of unmet medical needs, engaging communities and society, and improving lives for humans and animals. In ASKAN starting in 2022, we will be kicking off our regional and local activities to work with like-minded partners, governments and NGOs to focus on our sustainability goals focused on eliminating rabies (in dogs/cats), ensuring access to medicines (such as stroke care, through our Angels program), reducing plastic waste and saving energy in our offices, and working/donating to our local communities where our business operates in."

Production Date: April 2022
Item Code: MPR-TH-100091

The issuer is solely responsible for the content of this announcement.